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Of patients suffering from MCI, 5–15% progress to dementia every year ( 3). AD is the most common type of dementia with mild cognitive impairment (MCI) being a pre-dementia condition with a prevalence ranging from 16 to 20% of the population in those between 60 and 89 years old ( 2). Neurodegenerative disorders, including dementia and Alzheimer's Disease (AD), continue to represent a major social, healthcare and economic burden, worldwide ( 1). The ICA is unbiased by differences in language, culture, and education. In a separate study the ICA demonstrated no significant practise effect over the duration of the study.ĭiscussion: The ICA can support clinicians by aiding accurate diagnosis of MCI and AD and is appropriate for large-scale screening of cognitive impairment. The ICA correlation of 0.17 ( p = 0.01) with education years is considerably smaller than that of MoCA ( r = 0.34, p < 0.0001) and ACE ( r = 0.41, p < 0.0001) which displayed significant correlations. The AI model demonstrated improved performance with increased training data and showed generalisability in performance from one population to another. The ICA AI model was able to detect cognitive impairment with an AUC of 81% for MCI patients, and 88% for mild AD patients. Results: The ICA demonstrated convergent validity with MoCA (Pearson r=0.58, p<0.0001) and ACE (r=0.62, p<0.0001). 95 healthy volunteers, 80 MCI, and 55 mild AD participants completed the ICA, Montreal Cognitive Assessment (MoCA) and Addenbrooke's Cognitive Examination (ACE) cognitive tests. Methods: We studied the ICA in 230 participants. In this study, we aimed to evaluate the generalisability of the ICA in detecting cognitive impairment in MCI and mild AD patients.
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We developed the Integrated Cognitive Assessment (ICA) a 5-min, language independent computerised cognitive test that employs an Artificial Intelligence (AI) model to improve its accuracy in detecting cognitive impairment. Introduction: Early detection and monitoring of mild cognitive impairment (MCI) and Alzheimer's Disease (AD) patients are key to tackling dementia and providing benefits to patients, caregivers, healthcare providers and society. 6Tehran University of Medical Sciences, Tehran, Iran.5Department of Stem Cells and Developmental Biology, Cell Science Research Centre, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.4School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.3Department of Old Age Psychiatry, King's College London, London, United Kingdom.
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2South London & Maudsley NHS Foundation Trust, London, United Kingdom.1Cognetivity Ltd, London, United Kingdom.Chris Kalafatis 1,2,3 †, Mohammad Hadi Modarres 1 †, Panos Apostolou 1, Haniye Marefat 4, Mahdiyeh Khanbagi 5, Hamed Karimi 5, Zahra Vahabi 6, Dag Aarsland 3 and Seyed-Mahdi Khaligh-Razavi 1,5 *